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  • Title: Epoxide metabolites of protriptyline in rat urine.
    Author: Hucker HB, Balletto AJ, Demetriades J, Arison BH, Zacchei AG.
    Journal: Drug Metab Dispos; 1975; 3(2):80-4. PubMed ID: 236162.
    Abstract:
    Two epoxide metabolites of 5-(3-methylaminopropyl)-5H-dibenzo[a,d]cycloheptene (protriptyline) were identified in the urine of rats given 14-C-labeled drug. They were characterized by mass spectrometry, nuclear magnetic resonance spectrometry, and chemical reactivity as 10,11-dihydro-10,11-epoxy-5(3-methylaminopropyl)-5H-dibenzo[a,d]cycloheptene (I) and 10,11-dihydro-10,11-epoxy-5(3-aminopropyl)-5H-dibenzo[a,d]cycloheptene (II). Over twice as much I as II was excreted and together the two metabolites accounted for approximately 40% of the urinary radioactivity.
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