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  • Title: Investigation of in vitro antileishmanial activity of moxifloxacin, linezolid and caspofungin on Leishmania tropica promastigotes.
    Author: Limoncu ME, Eraç B, Gürpınar T, Özbilgin A, Balcıoğlu IC, Hoşgör-Limoncu M.
    Journal: Turkiye Parazitol Derg; 2013; 37(1):1-3. PubMed ID: 23619036.
    Abstract:
    OBJECTIVE: This study aimed to evaluate the potential in vitro anti-leishmanial activities of moxifloxacin, linezolid and caspofungin against Leishmania tropica. METHODS: In vitro effects of all agents were studied by using the microdilution method. For this purpose, serial dilutions of the aforementioned agents were prepared in concentrations between 4096 μg/mL-0.008 μg/mL. Afterwards, promastigotes incubated in suitable medium were counted with the hemocytometer and adjusted as having a last concentration of 2.5 x 10(6) cells/mL in wells containing medium+antibiotic or antifungal. After incubation live promastigotes were counted with the hemocytometer and inhibitor concentrations (IC(50)) were determined by comparing with the control that contained no antibiotics or antifungal. RESULTS: IC(50) values of moxiloxacin, linezolid and caspofungin were found as 194.7 μg/mL, 896 μg/mL and 235.7 μg/mL, respectively. CONCLUSION: As a result, moxifloxacin was found to be effective in lower concentrations than the other studied agents against L. tropica promastigotes.
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