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  • Title: [A receptor for UDP-glucose in the microsomal membranes of rat hepatocytes].
    Author: Frot-Coutaz J, Berthillier G, Got R.
    Journal: FEBS Lett; 1975 Mar 15; 52(1):81-4. PubMed ID: 236198.
    Abstract:
    Rat liver microsomal membranes have been shown to contain a biosynthetic pathway of UDP-glucose. In addition, they are able to bind UDP-glucose in a reversible manner, As UDP-glucose is also metabolized in these membranes, the study of the binding has been performed with a microsomal Triton X 100 extract. This reversible binding depends on pH (maximum at pH 8.1) and manganous ions, and disappears at pH 6.5. It exhibits a high affinity (K-diss equals 3 mu M), and a narrow specifity for UDP-glucose. Proteolytic digestion inhibits the binding up to 90%, showing that the UDP-glucose receptor has a proteic nature. These binding characteristics have been also found in the membranes themselves, indicating that the detergent solubilization does not destroy the protein binding capacity.
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