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  • Title: Cardiotoxicity in magnesium-deficient rats fed cadmium.
    Author: Nishiyama S, Saito N, Konishi Y, Abe Y, Kusumi K.
    Journal: J Nutr Sci Vitaminol (Tokyo); 1990 Feb; 36(1):33-44. PubMed ID: 2362223.
    Abstract:
    We studied the cardiotoxicity in magnesium (Mg)-deficient male rats fed 50 micrograms/g Cd for 45 consecutive days. Cd at a low concentration (0.28 ppm) in the heart induced cardiotoxic effects manifested by a decrease of the heart rate and weight and histopathological changes in the presence of Mg deficiency through Cd supplementation to a normal diet did not induce any cardiotoxic effect. Cardiac output (CO) did not increase in response to the decrease in the total peripheral resistance (TPR) in the Mg-deficient rats fed Cd, suggesting that supplementation of Cd to the Mg-deficient diet may lead to a decrease in the myocardial contractile function. However, supplementation of Cd to Mg-deficient diet also alleviated myocardial necrosis and Ca overload observed in the heart of Mg-deficient rats. The present data suggest that Cd ameliorates Ca overload in the heart of Mg-deficient rats but also may inhibit the release of Ca2+, which is a major determinant of the level of contractile force.
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