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  • Title: Physico-chemical comparison of famotidine tablets prepared via dry granulation and direct compression techniques.
    Author: Baseer A, Hassan F, Hassan SF, Jabeen S, Israr F, Murtaza G, Haque N.
    Journal: Pak J Pharm Sci; 2013 May; 26(3):439-43. PubMed ID: 23625414.
    Abstract:
    Famotidine is generally employed for the treatment of gastric ulcer. The present study was conducted to fabricate famotidine tablets using various diluents. The binder was incorporated to the formulations in different proportions. Both the dry granulation and direct compression techniques were employed to develop the tablets. Physical evaluation of tablets i.e. tablets hardness, friability, weight variation, thickness and diameter was determined. In vitro dissolution studies of the prepared tablets were carried out for 60 min using the USP apparatus II and 900 ml 0.1 M HCl stirred at 37 ± 0.5°C with a speed of 50 rpm. Physical analysis of tablets prepared via direct compression showed satisfactory results regarding the weight variation, hardness and friability, since their respective values were within the BP limits. All the prepared famotidine tablets exhibited diffusion based mode of drug release. 100% release of drug occurred in less than 60 min. The drug release from all the formulated tablets has elaborated the involvement of diffusion (Higuchian drug release). This comparative study exhibited that physical parameters of tablets are affected by the technique of tabletting.
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