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  • Title: [Efficiency of trimetazidine treatment of experimental ischemic heart disease in age aspect].
    Author: Kukes VG, Zhernakova NI, Gorbach TV, Romashchenko OV, Rumbesht VV.
    Journal: Eksp Klin Farmakol; 2013; 76(2):9-12. PubMed ID: 23631276.
    Abstract:
    Introduction of trimetazidine to 10-month-aged rats with experimental ischemic heart disease leads to an increase in carbohydrate utilization with energy purposes in myocardium, which is manifested by increasing activity of glycolysis enzymes with decreasing lactate level in myocardium, increasing activity of pyruvate dehydrogenase and citrate synthase in mitochondrial cardiomyocytes, and increasing ATP content in myocardium. This is accompanied by signs of stabilization of cardiomyocyte membranes and reduction in the degree of tissue hypoxia. The efficiency of trimetazidine decreases with increasing age: in 24-month-aged rats, the direction of changes is retained, but they are less pronounced.
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