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  • Title: [The effect of alpha-tocopherol and lidocaine on the structural-functional rearrangement of liver endoplasmic reticulum membranes after induction with phenobarbital in the postischemic period].
    Author: Sharapov VI, Grek OR, Zykov AA.
    Journal: Vopr Med Khim; 1990; 36(2):14-8. PubMed ID: 2363249.
    Abstract:
    Inhibition of an increase in total content of unsaturated fatty acids in microsomal lipids induced by phenobarbital, alterations of parameters of the fluorescent probe 1,8-ANS-binding with membranes as well as restrictions in induction of liver microsomal monooxygenase enzymatic system were detected during postischemic period after total liver tissue ischemia. Preadministration of alpha-tocopherol and lidocaine prevented distinctly the structure-functional alterations induced by phenobarbital in liver microsomal membranes during postischemic period. Possible factors responsible for limitations of the phenobarbital inducing effect during postischemic period are discussed.
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