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  • Title: [Fluorescent method of determination of serum albumin in hyperbilirubinemia].
    Author: Miller IuI, Iushko EG, Dobretsov GE, Krasovitskiĭ BM, Aĭdyraliev RK.
    Journal: Vopr Med Khim; 1990; 36(2):86-8. PubMed ID: 2363267.
    Abstract:
    A procedure is developed for estimation of human blood serum albumin in hyperbilirubinemia using a fluorescent probe 9,10-dianiline-2-sulfoanthracene (K-33). Use of the probe N-phenyl-I-amino-8-sulfonaphthalene (ANS) led to underestimation of albumin in hyperbilirubinemia as bilirubin and other inhibitors prevented the ANS binding with blood serum albumin. Substitution of ANS for K-33 enabled to estimate the albumin concentration under conditions of the pathology accompanied by an increase of endogenous ligands content in blood serum. The rate of K-33 (15 mM) fluorescence in blood serum (diluted 400-fold, at pH 4.0) correlated with albumin concentration (r-0.955).
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