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  • Title: 2',5' A synthetase: allosteric activation by fructose 1,6-bisphosphate.
    Author: Suhadolnik RJ, Li SW, Sobol RW, Varnum JM.
    Journal: Biochem Biophys Res Commun; 1990 Jun 29; 169(3):1198-203. PubMed ID: 2363721.
    Abstract:
    Fructose 1,6-bisphosphate (fru-1,6-P2), but not other glycolytic intermediates, activates highly purified 2',5' A synthetases from rabbit reticulocyte lysates and from 2',5'-ADP-agarose purified extracts of interferon-treated HeLa cells without the addition of dsRNA. The 2',5' A was structurally and biologically identical to authentic 2',5' A. Micrococcal nuclease inhibited the activation of 2',5' A synthetase by poly(I)-poly(C), but did not affect activation by fru-1,6-P2. Addition of fru-1,6-P2 aldolase prevented the activation of 2',5' A synthetase by fru-1,6-P2.
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