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  • Title: Synthesis, spectral and antimicrobial evaluation of some novel 1-methyl-3-alkyl-2,6-diphenylpiperidin-4-one oxime carbonates.
    Author: Sivakumar R, krishnan KG, Thanikachalam V.
    Journal: Bioorg Med Chem Lett; 2013 Jun 01; 23(11):3195-9. PubMed ID: 23639539.
    Abstract:
    Synthesis of some novel biologically active piperidin-4-one oxime carbonates from 1-methyl-3alkyl-2,6-diphenylpiperidin-4-one oximes and substituted chloroformates was carried out in the presence of potassium carbonate as base and tetrabutylammonium bromide (TBAB) as catalyst. The newly synthesized compounds were characterized by IR, (1)H, (13)C NMR and LC-mass spectra. Based on the (1)H NMR analysis, all the compounds were found to adopt normal chair conformation with equatorial orientation of all the substituents. For all the synthesized compounds (5a-5l) antimicrobial activity has been tested against bacterial and fungal strains using Streptomycin and Amphotericin B as standards.
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