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  • Title: Pathogenesis of aspirin-exacerbated respiratory disease and reactions.
    Author: Laidlaw TM, Boyce JA.
    Journal: Immunol Allergy Clin North Am; 2013 May; 33(2):195-210. PubMed ID: 23639708.
    Abstract:
    Physiologic and pharmacologic studies support the hypothesis that aspirin-exacerbated respiratory disease (AERD) involves fundamental dysregulation in the production of and end-organ responsiveness to both antiinflammatory eicosanoids (prostaglandin E2) and proinflammatory effectors (cysteinyl leukotrienes). The acquired nature of AERD implies a disturbance in a potential epigenetic control mechanism of the relevant mediator systems, which may be a result of incompletely clarified environmental factors (eg, viral or bacterial infections, inhaled pollutants).
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