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  • Title: Synthesis, antitumor evaluation and docking study of novel 4-anilinoquinazoline derivatives as potential epidermal growth factor receptor (EGFR) inhibitors.
    Author: Rao GW, Xu GJ, Wang J, Jiang XL, Li HB.
    Journal: ChemMedChem; 2013 Jun; 8(6):928-33. PubMed ID: 23640754.
    Abstract:
    Strike a pose! A series of 4-anilinoquinazolines were designed, synthesized and evaluated in vitro against lung and breast cancer cell lines. Several compounds were found to be endowed with cytotoxicity in the low micromolar range. Molecular docking suggests that these compounds bind to EGFR in a similar manner to known EGFR inhibitors.
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