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  • Title: Synthesis of new conjugated coumarin-benzimidazole hybrids and their anticancer activity.
    Author: Paul K, Bindal S, Luxami V.
    Journal: Bioorg Med Chem Lett; 2013 Jun 15; 23(12):3667-72. PubMed ID: 23642480.
    Abstract:
    A series of novel coumarin-benzimidazole hybrids, 3-(1H-benzo[d]imidazol-2-yl)-7-(substituted amino)-2H-chromen-2-one derivatives of biological interest were synthesized. Six out of the newly synthesized compounds were screened for in vitro antitumor activity against preliminary 60 tumor cell lines panel assay. A significant inhibition for cancer cells was observed with compound 8 (more than 50% inhibition) compared with other compounds and active known drug 5-fluorouracil (in some cell lines) as positive control. Compound 8 displayed appreciable anticancer activities against leukemia, colon cancer and breast cancer cell lines.
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