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  • Title: Extensive diversification is a common feature of Pseudomonas aeruginosa populations during respiratory infections in cystic fibrosis.
    Author: Ashish A, Paterson S, Mowat E, Fothergill JL, Walshaw MJ, Winstanley C.
    Journal: J Cyst Fibros; 2013 Dec; 12(6):790-3. PubMed ID: 23642644.
    Abstract:
    BACKGROUND: Populations of the Liverpool Epidemic Strain (LES) of Pseudomonas aeruginosa undergo extensive diversification in the cystic fibrosis (CF) lung during long-term chronic infections. METHODS: We analyzed sets of 40 isolates from the sputa of five CF patients, each chronically infected with a different non-LES strain of P. aeruginosa. For each sample (two per patient), diversity was assessed by characterizing nine phenotypic traits. RESULTS: All P. aeruginosa populations were highly diverse, with the majority of phenotypic variation being due to within-sample diversity. CONCLUSIONS: Maintenance of diverse populations in the CF lung is a common feature of P. aeruginosa infections.
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