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  • Title: [Genetic polymorphisms of four SNP loci in D5 gene of dopamine receptor in Northern Chinese Han population].
    Author: Zhao Y, Ding M, Pang H, Xing JX, Xuan JF, Yao J, Sun YH, Wang BJ.
    Journal: Fa Yi Xue Za Zhi; 2013 Feb; 29(1):37-8, 48. PubMed ID: 23646502.
    Abstract:
    OBJECTIVE: To reveal the genetic polymorphisms of four SNP loci (rs77434921, rs2076907, rs6283, rs1800762) in D5 gene of dopamine receptor (DRD5) in Northern Chinese Han population. METHODS: Four SNP loci of the DRD5 gene of 206 unrelated individuals in Northern Chinese Han population were separately amplified and sequenced by PCR technique and statistically analyzed by Haploview v4.1 software. RESULTS: In Northern Chinese Han population, the genotype frequency distribution of rs77434921, rs2076907, rs6283 and rs1800762 loci in the DRD5 gene were all in accordance with Hardy-Weinberg equilibrium. DP value was 0.145, 0.532, 0.602 and 0.159, while PE value was 0.004, 0.079, 0.196 and 0.007. A linkage disequilibrium among these four SNP loci was also demonstrated, which might infer five haplotypes. CONCLUSION: rs2076907 and rs6283 loci of DRD5 gene in the Northern Chinese Han population have high genetic polymorphisms, which can be useful for forensic identification of individuals.
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