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  • Title: Rhazinilam-Leuconolam-Leuconoxine Alkaloids from Leuconotis griffithii.
    Author: Gan CY, Low YY, Thomas NF, Kam TS.
    Journal: J Nat Prod; 2013 May 24; 76(5):957-64. PubMed ID: 23647487.
    Abstract:
    Eight new indole alkaloids (1-8) belonging to the rhazinilam-leuconolam-leuconoxine group, in addition to 52 other alkaloids, were isolated from the stem-bark extract of Leuconotis griffithii, viz., nor-rhazinicine (1), 5,21-dihydrorhazinilam-N-oxide (2), 3,14-dehydroleuconolam (3), and leuconodines A-E (4-8). The structures of these alkaloids were determined using NMR and MS analyses and in some instances confirmed by X-ray diffraction analyses. Alkaloids 1, 5, and 7 showed only moderate to weak cytotoxicity toward KB cells (IC50 12-18 μg/mL), while 8 showed moderate activity in reversing MDR in vincristine-resistant KB cells.
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