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  • Title: Validation of finite element model of transcranial electrical stimulation using scalp potentials: implications for clinical dose.
    Author: Datta A, Zhou X, Su Y, Parra LC, Bikson M.
    Journal: J Neural Eng; 2013 Jun; 10(3):036018. PubMed ID: 23649036.
    Abstract:
    OBJECTIVE: During transcranial electrical stimulation, current passage across the scalp generates voltage across the scalp surface. The goal was to characterize these scalp voltages for the purpose of validating subject-specific finite element method (FEM) models of current flow. APPROACH: Using a recording electrode array, we mapped skin voltages resulting from low-intensity transcranial electrical stimulation. These voltage recordings were used to compare the predictions obtained from the high-resolution model based on the subject undergoing transcranial stimulation. MAIN RESULTS: Each of the four stimulation electrode configurations tested resulted in a distinct distribution of scalp voltages; these spatial maps were linear with applied current amplitude (0.1 to 1 mA) over low frequencies (1 to 10 Hz). The FEM model accurately predicted the distinct voltage distributions and correlated the induced scalp voltages with current flow through cortex. SIGNIFICANCE: Our results provide the first direct model validation for these subject-specific modeling approaches. In addition, the monitoring of scalp voltages may be used to verify electrode placement to increase transcranial electrical stimulation safety and reproducibility.
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