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  • Title: Desired vancomycin trough serum concentration for treating invasive methicillin-resistant Staphylococcal infections.
    Author: Frymoyer A, Guglielmo BJ, Hersh AL.
    Journal: Pediatr Infect Dis J; 2013 Oct; 32(10):1077-9. PubMed ID: 23652479.
    Abstract:
    Vancomycin area under the curve/minimal inhibitory concentration (AUC/MIC) >400 best predicts the outcome when treating invasive methicillin-resistant Staphylococcus aureus infection; however, trough serum concentrations are used clinically to assess the appropriateness of dosing. We used pharmacokinetic modeling and simulation to examine the relationship between vancomycin trough values and AUC/MIC in children receiving vancomycin 15 mg/kg every 6 hours and methicillin-resistant Staphylococcus aureus MIC of 1 μg/mL. A trough of 7-10 μg/mL predicted achievement of AUC/MIC >400 in >90% of children.
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