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  • Title: Design, synthesis, and evaluation of indolebutylamines as a novel class of selective dopamine D3 receptor ligands.
    Author: Du P, Xu L, Huang J, Yu K, Zhao R, Gao B, Jiang H, Zhao W, Zhen X, Fu W.
    Journal: Chem Biol Drug Des; 2013 Sep; 82(3):326-35. PubMed ID: 23663349.
    Abstract:
    A series of indolebutylamine derivatives were designed, synthesized, and evaluated as a novel class of selective ligands for the dopamine 3 receptor. The most potent compound 11q binds to dopamine 3 receptor with a Ki value of 124 nm and displays excellent selectivity over the dopamine 1 receptor and dopamine 2 receptor. Investigation based on structural information indicates that site S182 located in extracellular loop 2 may account for high selectivity of compounds. Interaction models of the dopamine 3 receptor-11q complex and structure-activity relationships were discussed by integrating all available experimental and computational data with the eventual aim to discover potent and selective ligands to dopamine 3 receptor.
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