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  • Title: [Mathematical model of intracranial blood-cerebrospinal fluid dynamics system applied to the study of extreme conditions].
    Author: Grigorian SS, Simonov LG, Tsaturian AK.
    Journal: Kosm Biol Aviakosm Med; 1990; 24(2):25-9. PubMed ID: 2366500.
    Abstract:
    A mathematical model of cerebral blood and lymph circulation that can be used to study various effects (simulated space flight factors, functional loads) on the human body was developed. Biophysical patterns that determine relationships between cerebral blood and lymph circulation as well as between fluid volumes and pressures (P and V) are discussed. Involvement of the mechanism of brain circulation autoregulation in cerebral blood and lymph circulation is considered. The model was applied to study responses of cerebral blood and lymph circulation to various exposures such as orthostatic and antiorthostatic tests and provocative tests which led to intracranial pressure shifts and modified the ratio between volumes and pressures in different hydrodynamic systems. The modelling data were consistent with clinical, physiological and experimental observations which demonstrate an adequacy of the above model.
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