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  • Title: Multiple-dosing effects of benzo[a]pyrene in the mouse bone marrow micronucleus test.
    Author: Shimada H, Satake S, Itoh S, Hattori C, Hayashi M, Ishidate M.
    Journal: Mutat Res; 1990; 234(3-4):179-81. PubMed ID: 2366787.
    Abstract:
    Multiple-dosing effects of benzo[a]pyrene (B[a]P) in the micronucleus test were studied using CD-1 male mice. Mice were treated orally once, twice or 3 times with 250, 500, 1000 or 2000 mg/kg, at 24-h intervals. Bone marrow cells were sampled 24 h after the last administration. The present study indicated that the incidence of polychromatic erythrocytes with micronuclei significantly increased more in the group of animals that received B[a]P twice than in those receiving it one or 3 times. The dose of 500 mg/kg B[a]P yielded the greatest response of any dose regimen.
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