These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Study on andrographolide solid dispersion vectored by hydroxyapatite].
    Author: Hu SY, Zhang ZH, Jia XB.
    Journal: Zhongguo Zhong Yao Za Zhi; 2013 Feb; 38(3):341-5. PubMed ID: 23668005.
    Abstract:
    OBJECTIVE: To prepare andrographolide solid dispersion, with hydroxyapatite as vector, in order to increase drug dissolution. METHOD: Andrographolide and hydroxyapatite were dispersed in 95% ethanol. The solvent evaporation method was adopted to prepare andrographolide solid dispersion, in order to study its dissolution behavior, stability and physical characteristics. RESULT: The solid dispersion prepared with andrographolide and hydroxyapatite with the proportion of 1:8 existed in the vector in an amorphous form, according to differential scanning calorimetry, scanning electron microscopy and X-ray powder diffraction. The in vitro dissolution of andrographolide solid dispersions was up to 93% at 45 min. After the accelerated stability test for three months, the drug dissolution and content in andrographolide solid dispersion showed no significant change. CONCLUSION: The prepared solid dispersions with hydroxyapatite as the vector can effectively improve the stability and dissolution of water-insoluble drug andrographolide.
    [Abstract] [Full Text] [Related] [New Search]