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  • Title: Molecularly imprinted poly(hydroxyethyl methacrylate) based cryogel for albumin depletion from human serum.
    Author: Andac M, Galaev IY, Denizli A.
    Journal: Colloids Surf B Biointerfaces; 2013 Sep 01; 109():259-65. PubMed ID: 23668981.
    Abstract:
    Macroporous cryogels imprinted with human serum albumin (HSA) have been prepared by copolymerization of 2-hydroxyethyl methacrylate with a functional co-monomer of N-methacryloyl-L-phenylalanine. The cryogels were used for the depletion of HSA from human serum. HSA-imprinted cryogels were prepared with gel fraction yields up to 90%, and their chemical structure, morphology and porosity were characterized by FTIR-spectroscopy, scanning electron microscopy, swelling studies and flow dynamics. Selective binding experiments were performed in the presence of competitive proteins like human transferrin and myoglobin. Albumin-imprinted cryogel column was optimized for fast protein liquid chromatography. Sodium-dodecyl sulfate polyacrylamide gel electrophoresis was used to show the efficiency of albumin depletion.
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