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  • Title: Conjunctival surface damage distribution in keratoconjunctivitis sicca. An impression cytology study.
    Author: Rolando M, Terragna F, Giordano G, Calabria G.
    Journal: Ophthalmologica; 1990; 200(4):170-6. PubMed ID: 2367078.
    Abstract:
    Impression cytology was used to study the ocular surface of 32 eyes with keratoconjunctivitis sicca. Among these eyes, on the basis of the results of the Schirmer I test, two groups of eyes have been identified. The first group with Schirmer test less than 5.5 mm/5 min showed decreased concentration of goblet cells and increased cytoplasm/nucleus ratio on all the areas of the bulbar conjunctiva. The second group, with Schirmer test greater than 5.5 mm/5 min, showed similar changes to be localized in the interpalpebral bulbar conjunctiva only, while the eye surface protected by the lids was almost normal. These observations suggest a pathogenetic role of tear evaporation in eyes with tear film instability even in the presence of a 'theoretically' normal tear production.
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