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  • Title: Remarkable antioxidant properties of a series of hydroxy-3-arylcoumarins.
    Author: Matos MJ, Pérez-Cruz F, Vazquez-Rodriguez S, Uriarte E, Santana L, Borges F, Olea-Azar C.
    Journal: Bioorg Med Chem; 2013 Jul 01; 21(13):3900-6. PubMed ID: 23673214.
    Abstract:
    In the present work we synthesized a series of hydroxy-3-arylcoumarins (compounds 1-9), some of them previously described as MAO-B selective inhibitors, with the aim of evaluating their antioxidant properties. Theoretical evaluation of ADME properties of all the derivatives was also carried out. From the ORAC-FL, ESR and CV data it was concluded that these derivatives are very good antioxidants, with a very interesting hydroxyl, DPPH and superoxide radicals scavenging profiles. In particular compound 9 is the most active and effective antioxidant of the series (ORAC-FL=13.5, capacity of scavenging hydroxyl radicals=100%, capacity of scavenging DPPH radicals=65.9% and capacity of scavenging superoxide radicals=71.5%). Kinetics profile for protection fluorescein probe against peroxyl radicals by addition of antioxidant molecule 9 was also performed. Therefore, it can operate as a potential candidate for preventing or minimizing the free radicals overproduction in oxidative-stress related diseases.
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