These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: CT stress perfusion imaging for detection of haemodynamically relevant coronary stenosis as defined by FFR.
    Author: Greif M, von Ziegler F, Bamberg F, Tittus J, Schwarz F, D'Anastasi M, Marcus RP, Schenzle J, Becker C, Nikolaou K, Becker A.
    Journal: Heart; 2013 Jul; 99(14):1004-11. PubMed ID: 23674364.
    Abstract:
    OBJECTIVES: To evaluate the diagnostic accuracy (DA) of CT-myocardial perfusion imaging (CT-MPI) and a combined approach with CT angiography (CTA) for the detection of haemodynamically relevant coronary stenoses in patients with both suspected and known coronary artery disease. DESIGN: Prospective, non-randomised, diagnostic study. SETTING: Academic hospital-based study. PATIENTS: 65 patients (42 men age 70.4±9) with typical or atypical chest pain. INTERVENTIONS: CTA and CT-MPI with adenosine stress using a fast dual-source CT system. At subsequent invasive angiography, FFR measurement was performed in coronary arteries to define haemodynamic relevance of stenosis. MAIN OUTCOME MEASURES: We tried to correlate haemodynamically relevant stenosis (FFR < 0.80) to a reduced myocardial blood flow (MBF) as assessed by CT-MPI and determined the DA of CT-MPI for the detection of haemodynamically relevant stenosis. RESULTS: Sensitivity and negative predictive value (NPV) of CTA alone were very high (100% respectively) for ruling out haemodynamically significant stenoses, specificity, Positive predictive value (PPV) and DA were low (43.8, 67.3 and 72%, respectively). CT-MPI showed a significant increase in specificity, PPV and DA for the detection of haemodynamically relevant stenoses (65.6, 74.4 and 81.5%, respectively) with persisting high sensitivity and NPV for ruling out haemodynamically relevant stenoses (97% and 95.5% respectively). The combination of CTA and CT-MPI showed no further increase in detection of haemodynamically significant stenosis compared with CT-MPI alone. CONCLUSIONS: Our data suggest that CT-MPI permits the detection of haemodynamically relevant coronary artery stenoses with a moderate DA. CT may, therefore, allow the simultaneous assessment of both coronary morphology and function.
    [Abstract] [Full Text] [Related] [New Search]