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  • Title: Effect of rebamipide ophthalmic suspension on optical quality in the short break-up time type of dry eye.
    Author: Koh S, Inoue Y, Sugmimoto T, Maeda N, Nishida K.
    Journal: Cornea; 2013 Sep; 32(9):1219-23. PubMed ID: 23676786.
    Abstract:
    PURPOSE: To determine the effect of rebamipide ophthalmic suspension on optical quality in patients with dry eye with short break-up time (BUT) of the tear film. METHODS: Twenty-six eyes of 16 patients with the short BUT type of dry eye were enrolled and treated with 2% rebamipide ophthalmic suspension. At baseline and at 2 and 4 weeks after initiating the treatment, the serial corneal higher-order aberrations (HOAs), BUT, fluorescein staining, and Schirmer test were measured. Patients were asked to complete questionnaires about the changes in dry eye-related ocular symptoms after the treatment. RESULTS: Before the treatment, the pattern of postblink corneal HOAs for 10 seconds showed a sawtooth pattern, with a marked upward curve that increased after blinking. Treatment with rebamipide for 4 weeks significantly (P < 0.05) improved the postblink corneal HOAs and stabilized the pattern of the corneal HOAs. Significant increases in the tear film BUT were seen 2 and 4 weeks after the treatment (P < 0.001 for both comparisons). CONCLUSIONS: Rebamipide administered to treat the short BUT type of dry eye significantly improved optical quality because of the improvement in tear stability.
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