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  • Title: Ln[N(SiMe3)2]3-catalyzed cycloaddition of terminal alkynes to azides leading to 1,5-disubstituted 1,2,3-triazoles: new mechanistic features.
    Author: Hong L, Lin W, Zhang F, Liu R, Zhou X.
    Journal: Chem Commun (Camb); 2013 Jun 21; 49(49):5589-91. PubMed ID: 23676902.
    Abstract:
    The first example of rare earth metal-catalyzed cycloaddition of terminal alkynes to azides resulting in the formation of 1,5-disubstituted 1,2,3-triazoles is described. Preliminary studies revealed that the present cycloaddition shows unprecedented mechanistic features involving a tandem anionic cascade cyclization and anti-addition across the C≡C triple bond.
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