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  • Title: A new bioactive sesquiterpenoid quinone from the Mediterranean Sea marine sponge Dysidea avara.
    Author: Hamed AN, Wätjen W, Schmitz R, Chovolou Y, Edrada-Ebel R, Youssef DT, Kamel MS, Proksch P.
    Journal: Nat Prod Commun; 2013 Mar; 8(3):289-92. PubMed ID: 23678793.
    Abstract:
    Investigation of the marine sponge Dysidea avara, family Dysideidae, afforded a new sesquiterpene (-)-N-methylmelemeleone-A (5), in addition to four known sesquiterpenes (+)-avarol (1), (+)-avarone (2), (-)-3'-methylaminoavarone (3) and (-)-4'-methylaminoavarone (4). The structure elucidation of compound 5 was based on 1D and 2D NMR spectroscopic, and HR-MS studies, as well as by comparison with the literature. Cytotoxicity, proteinkinase inhibition, inhibition of NFkB-activity and insecticidal activity were evaluated for the isolated compounds.
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