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  • Title: Relief of duodenal ulcer sysmptons by oral metiamide.
    Author: Pounder RE, Williams JG, Milton-Thompson GJ, Misiewicz JJ.
    Journal: Br Med J; 1975 May 10; 2(5966):307-9. PubMed ID: 236804.
    Abstract:
    Thirty patients with symptoms of duodenal ulceration were treated for five to eight weeks in a double-blind trial with either metiamide 1 g daily by mouth or a placebo. In the 15 patients receiving metiamide there were significant reductions in nocturnal pain and antacid consumption. Daytime pain was diminished. The results suggest that histamine H2-receptor antagonists are likely to be useful in the medical management of the symptoms of duodenal ulceration.
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