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  • Title: A novel topical rapamycin cream for the treatment of facial angiofibromas in tuberous sclerosis complex.
    Author: Wheless JW, Almoazen H.
    Journal: J Child Neurol; 2013 Jul; 28(7):933-6. PubMed ID: 23680945.
    Abstract:
    Facial angiofibromas are dermatological manifestations of tuberous sclerosis complex, a neurocutaneous disorder characterized by excess cell growth and proliferation. Oral rapamycin has been used to treat visceral tuberous sclerosis-related tumors; however, the side effect profile of this medicine precludes its routine use in patients lacking significant internal involvement. The authors formulated a novel rapamycin cream that is easy to compound and apply, does not cause local or systemic side effects, and results in a dramatic improvement of facial angiofibromas.
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