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  • Title: [The effect of combined drug treatment on rheologic properties of the blood in patients with disordered circulatory encephalopathy].
    Author: Ishchenko MM, Ostrovskaia OS.
    Journal: Vrach Delo; 1990 Mar; (3):58-60. PubMed ID: 2368364.
    Abstract:
    The effect of vasoactive agents, nootropic drugs and cerebrolysin on blood viscosity was studied in 128 patients with atherosclerotic disordered circulatory encephalopathy. Vasoactive and nootropic agents excluding cerebrolysin reduced blood viscosity, spontaneous aggregation of erythrocytes and thrombocytes. The most pronounced effect in reducing blood viscosity and aggregation properties of erythrocytes produced by sermion, pentoxyphyllin and pyriditol while the spontaneous aggregation of thrombocytes was reduced by calcium antagonists (corinfar, phynoptin) and pentoxyphyllin. Cerebrolysin produced a marked effect on erythrocytes, elevation of blood viscosity. Hence, its use in patients with ischemic blood circulation disorders requires cautious approach.
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