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  • Title: Effects of VM-26 and lonidamine on a B16 melanoma cell line.
    Author: Bellelli A, Bellelli L, Di Palma M, Lorenzon I, Mattioni M, Nista A, Pavese I, Rusconi V, Sezzi ML.
    Journal: Anticancer Res; 1990; 10(3):565-77. PubMed ID: 2369079.
    Abstract:
    The treatment of exponentially-growing B16 melanoma cells with teniposide causes a dose- and time-dependent decrease of cell survival. By means of the nucleoid technique, the formation of double strand breaks was demonstrated in the nuclei of the treated cells, indicating a possible involvement of topoisomerase II. DNA double strand breaks were rapidly but ineffectively repaired. Morphometric and densitometric analyses showed that teniposide treatment causes a considerable increase of nuclear area, nuclear DNA and cell size, associated with a lowering of the mitotic index to less than one hundredth of that of the controls. The cytocidal effect of VM-26 can be potentiated by the addition of a non-lethal dose of lonidamine, whose synergism is particularly evident at low teniposide concentrations.
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