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  • Title: Comparison of phytohemagglutinin-induced cutaneous hypersensitivity reactions in the interdigital skin of broiler and layer chicks.
    Author: Corrier DE.
    Journal: Avian Dis; 1990; 34(2):369-73. PubMed ID: 2369376.
    Abstract:
    Cutaneous basophil hypersensitivity (CBH) responses elicited by intradermal injection of phytohemagglutinin-P (PHA-P) were evaluated in the interdigital skin of broiler and layer chicks. Five- and 10-day-old broiler and layer chicks were injected intradermally in the interdigital skin between the third and fourth digits of the right foot with 25, 50, or 100 micrograms of PHA-P. The PHA-P-elicited CBH responses were evaluated by determining interdigital skin thickness before injection and 12 and 24 hr after injection. The effect of treatment with the T-lymphocyte-suppressing drug cyclosporin on the CBH responses was determined in chicks treated daily for 4 days before skin-testing at 10 days of age. Injection of PHA-P caused significant increases (P less than 0.005) in skin thickness at all dose amounts, with the maximum CBH response elicited by 100 micrograms PHA-P. The CBH response was significantly higher (P less than 0.05) in broilers than in layers. Treatment with cyclosporin significantly suppressed (P less than 0.01) the CBH response in 10-day-old chicks of both types. Results indicate that the interdigital skin-test is a rapid, simple means of assessing normal and suppressed T-lymphocyte-mediated immune response in broiler and layer chicks.
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