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  • Title: Veno-occlusive disease of the liver complicating ABMT successfully treated with recombinant tissue plasminogen activator (rt-PA).
    Author: Baglin TP, Harper P, Marcus RE.
    Journal: Bone Marrow Transplant; 1990 Jun; 5(6):439-41. PubMed ID: 2369685.
    Abstract:
    A 45-year-old man underwent autologous bone marrow transplantation for relapsed myeloma. The procedure was complicated by the development of veno-occlusive disease (VOD) of the liver. Thrombolytic therapy with recombinant tissue plasminogen activator (rt-PA) resulted in rapid resolution of hepatic encephalopathy and ascites with improvement in liver function. The use of rt-PA in the management of VOD appears effective and should be evaluated in further patients.
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