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  • Title: Relationship between bone mineral density, weight, and estrogen levels in pre and postmenopausal women.
    Author: Corina M, Vulpoi C, Brănişteanu D.
    Journal: Rev Med Chir Soc Med Nat Iasi; 2012; 116(4):946-50. PubMed ID: 23700870.
    Abstract:
    UNLABELLED: Bone loss in postmenopausal women is mainly due to estrogen deficiency affecting the balance between osteoclast resorption and bone formation controlled by osteoblasts. AIM: To determine the relationship between bone mineral density (BMD) in pre and postmenopausal Caucasian women, and estrogen levels. MATERIAL AND METHODS: Cross-sectional study including six groups of 8 to 15 pre- and postmenopausal healthy volunteers with different weights, body mass index (BMI) (normal or underweight < 25 kg/m2, overweight 25-30 kg/m2, and obese > 30 kg/m2), not exposed to antiosteoporotic therapy. Lumbar bone mineral density (BMD) and body composition (BC) were evaluated by dual X ray absorptiometry (DXA, Hologic), while serum estradiol and estrone were measured by ELISA. RESULTS: BMD in postmenopausal women is lower than in premenopausal women irrespective of body weight (p<0.05). Estradiol and estrone are positively correlate with bone mass in premenopausal women, but not in postmenopausal women (R2 0.3209, R2 0.2579, respectively). CONCLUSIONS: It is very important to identify the risk factors for osteoporosis, especially in postmenopausal women, as we will show that aromatization of androgens into estrogens in adipose tissue appears not to have a significant role in postmenopausal women bone protection. Key-
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