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  • Title: A new polyketide from Diaporthe sp. SXZ-19, an endophytic fungal strain of Camptotheca acuminate.
    Author: Liu Y, Hu Z, Lin X, Lu C, Shen Y.
    Journal: Nat Prod Res; 2013; 27(22):2100-4. PubMed ID: 23701441.
    Abstract:
    A new polyketide named (1R,2E,4S,5R)-1-[(2R)-5-oxotetrahydrofuran-2-yl]-4,5-dihydroxy-hex-2-en-1-yl(2E)-2-methylbut-2-enoate (1), along with eight known polyketide including one monoterpene (2), three linear furanopolyketides (3-5) and four lovastatin analogues (6-9), was isolated from the endophytic fungal strain Diaporthe sp. SXZ-19 of Camptotheca acuminate. The chemical structures of compounds 1-9 were elucidated on the basis of extensive spectroscopic analyses, including FT-ICR-MS, IR and 1D and 2D NMR experiments. The in vitro cytotoxicity of 1 against the human colon cancer cell line HCT 116 was evaluated but showed no evident activity.
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