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  • Title: A common gene variant in STK11 is associated with metabolic risk markers and diabetes during gestation.
    Author: Bassols J, Megia A, Soriano-Rodríguez P, Díaz M, Prats-Puig A, Gifre M, Simón-Muela I, Torrent S, Borrell AC, Riera-Socasau JC, Vendrell J, de Zegher F, Ibáñez L, López-Bermejo A.
    Journal: Fertil Steril; 2013 Sep; 100(3):788-92. PubMed ID: 23706335.
    Abstract:
    OBJECTIVE: To assess whether the common rs8111699 (C528G) variant in STK11 is related to metabolic risk markers in pregnant women and to gestational diabetes mellitus (GDM). DESIGN: Cross-sectional study. SETTING: Hospital. PATIENT(S): A total of 561 pregnant women: 318 without and 243 with GDM (National Diabetes Data Group criteria). INTERVENTION(S): None. MAIN OUTCOME MEASURES(S): rs8111699 variant in STK11 (Taqman technology). Fasting glucose, insulin (homeostatic model assessment of insulin resistance and β-cell function [HOMA-IR and -β]) and C-peptide assessed at 24-28 weeks' gestation. RESULT(S): In non-GDM women, the G allele in rs8111699 was associated with lower HOMA-IR (CC: 1.3 ± 0.1 mIU/L; GG: 0.9 ± 0.1 mIU/L) and HOMA-β (CC: 165 ± 20 mIU/L; GG: 118 ± 10 mIU/L). In GDM women, the G allele was related to lower body mass index (BMI; CC: 27.9 ± 1.0 kg/m(2); GG: 24.5 ± 0.6 kg/m(2)) and C-peptide (CC: 2.3 ± 0.1 ng/mL; GG: 1.6 ± 0.1 ng/mL). The GG genotype was less frequently observed in GDM women (18% vs. 26%), particularly in heavier GDM women (BMI > median: 14% vs. 28%). CONCLUSION(S): In pregnant women, the G allele for the rs8111699 variant in STK11 is associated with a more favorable metabolic phenotype and may protect against the development of GDM, particularly in heavier women.
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