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  • Title: Investigation of the beta 2-agonist properties of dilevalol: metabolic effects of intravenous infusion.
    Author: Kendall MJ, Lewis HM, Haffner CA, Hughes BA.
    Journal: J Hum Hypertens; 1990 Jun; 4 Suppl 2():65-8. PubMed ID: 2370646.
    Abstract:
    We describe two studies which investigate the beta 2-agonist properties of dilevalol. We have previously demonstrated, by giving an infusion of terbutaline to human volunteers, that beta 2-stimulation causes a rise in plasma glucose and a fall in plasma potassium. These metabolic effects can be prevented by prior beta-blockade. We now show that infusion of dilevalol produces similar, but quantitatively smaller, metabolic effects at a dose which also produces clinically significant beta-blockade, as judged by a fall in exercise heart rate. This adds support to the claim that dilevalol is a non-selective beta-blocker with selective beta 2-agonist activity.
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