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  • Title: Anti-neuroinflammatory diarylheptanoids from the rhizomes of Dioscorea nipponica.
    Author: Woo KW, Moon E, Kwon OW, Lee SO, Kim SY, Choi SZ, Son MW, Lee KR.
    Journal: Bioorg Med Chem Lett; 2013 Jul 01; 23(13):3806-9. PubMed ID: 23707257.
    Abstract:
    In a continuing search for bioactive constituents from Dioscoreaceae medicinal plants, two new cyclic diarylheptanoids, diosniponol A (1) and B (2), together with 10 known compounds (3-12) were isolated from the rhizomes of Dioscorea nipponica. The structures of these new compounds were determined by spectroscopic analyses, including extensive two-dimensional nuclear magnetic resonance, high-resolution mass spectrometry, and optical rotation. All isolated compounds 1-12 were evaluated for their effects on nitric oxide (NO) production in murine microglia cell line BV-2. Compounds 8 and 11 showed potent inhibitory activities on NO production (IC50 13.36 and 14.36 μM, respectively) without cell toxicity in lipopolysaccharide-activated BV-2 cells.
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