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  • Title: Neuropsychological impairment in children with Rolandic epilepsy and in their siblings.
    Author: Verrotti A, Matricardi S, Di Giacomo DL, Rapino D, Chiarelli F, Coppola G.
    Journal: Epilepsy Behav; 2013 Jul; 28(1):108-12. PubMed ID: 23708147.
    Abstract:
    To assess and characterize a possible neurocognitive endophenotype associated with Rolandic epilepsy (RE), a clinical study was carried out to evaluate the neuropsychological profile of children with RE at onset and of their healthy siblings. Seventeen subjects were recruited (10 boys and 7 girls): nine patients affected by RE and eight siblings who underwent clinical and neuropsychological evaluations. All patients and only two siblings showed centrotemporal spikes on the electroencephalographic recording. Eighteen age- and sex-matched healthy children were assessed as controls. A significant impairment was found in language domain, attentional functioning, and short- and long-term verbal memory in both patients and siblings. A positive correlation between verbal comprehension and working memory scores was found in both groups. A similar neuropsychological profile of RE, which affected patients and their siblings with impairment in the same developing areas, supports the hypothesis of a specific neurocognitive phenotype in RE.
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