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  • Title: [The effects of RH 421 on the activity of amphotericin B in cell and model membranes].
    Author: Mikhaĭlova EV, Efimova SS, Ostroumova OS.
    Journal: Tsitologiia; 2013; 55(2):136-9. PubMed ID: 23718076.
    Abstract:
    The combined action of polyene macrolide antibiotic amphotericin B and styryl dye RH 421 in model lipid membranes and in yeast Saccharomyces cerevisiae has been studied. RH 421 insertion inti the ergosterol-containing lipid bilayers led to the increase of the steady-state number of open amphotericin channels by 8.5 +/- 3.2 times. Paper disk agar diffusion method has demonstrated that RH 421 enhanced the antimicrobial effect of amphotericin B leading to an increase in the zone of growth inhibition of S. cerevisiae strain by 1.5 times. Our data suggest that RH 421 is a potential synergist of amphotericin B and can be used in new formulations with improved pharmacological properties.
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