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  • Title: Assessment of a commercially available point-of-care assay for the measurement of bovine cardiac troponin I concentration.
    Author: Fraser BC, Anderson DE, White BJ, Miesner MD, Wheeler C, Amrine D, Lakritz J, Overbay T.
    Journal: Am J Vet Res; 2013 Jun; 74(6):870-3. PubMed ID: 23718655.
    Abstract:
    OBJECTIVE: To assess a commercially available point-of-care assay for measurement of bovine cardiac troponin I (cTnI) concentration in blood and plasma samples. SAMPLE: Prepared bovine plasma standard samples with known concentrations (0 to 1.0 ng/mL) of cTnI and blood and plasma samples obtained from 28 healthy 2.5-month-old Holstein calves. PROCEDURES: Coefficients of variation were calculated for concentrations of cTnI in prepared standards determined with the point-of-care assay, and values were compared with the known concentrations. The cTnI concentrations in blood samples obtained from calves determined with the point-of-care assay were compared with cTnI concentrations in plasma samples obtained from those animals determined with a validated immunoassay. RESULTS: The coefficients of variation of cTnI concentrations determined for prepared standards by use of the point-of-care assay were low (< 20%) for standards with cTnI concentrations ≥ 0.025 ng/mL. The blood cTnI concentrations determined with the point-of-care assay were not significantly different from the plasma cTnI concentrations determined with the validated immunoassay. CONCLUSIONS AND CLINICAL RELEVANCE: Results of this study indicated the point-of-care assay had high precision for determination of cTnI concentrations in most evaluated prepared bovine plasma standard samples. The point-of-care assay may be useful for determination of circulating concentrations of cTnI in cattle.
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