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  • Title: Synthesis of eukaryotic translation elongation inhibitor lactimidomycin via Zn(II)-mediated Horner-Wadsworth-Emmons macrocyclization.
    Author: Larsen BJ, Sun Z, Nagorny P.
    Journal: Org Lett; 2013 Jun 21; 15(12):2998-3001. PubMed ID: 23731327.
    Abstract:
    An enantioselective synthesis of potent eukaryotic translation elongation inhibitor lactimidomycin has been accomplished in 21 linear steps. This synthesis features a Zn(II)-mediated Horner-Wadsworth-Emmons reaction that could be executed on a large scale to provide the highly strained 12-membered lactimidomycin macrolactone.
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