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  • Title: Metabolism of the diuretic bumetanide in healthy subjects and patients with renal impairment.
    Author: Howlett MR, Skellern GG, Auld WH, Murdoch WR.
    Journal: Eur J Clin Pharmacol; 1990; 38(6):583-6. PubMed ID: 2373133.
    Abstract:
    The pharmacokinetics and metabolism of orally administered bumetanide were studied in five healthy subjects and in five patients with renal insufficiency. Healthy subjects excreted 51% of the dose as unchanged drug in the urine, whilst the patients with renal insufficiency excreted only 11% of the dose as bumetanide. Similarly the urinary excretion of the gamma-hydroxybutyl metabolite was reduced from 6% in healthy subjects to 2.3% in patients with renal impairment. In both groups of subjects the mean elimination half-life of the metabolite was greater than for bumetanide. The results indicate a possible accumulation of bumetanide and metabolite in patient with renal failure.
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