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  • Title: Role of oxidants on calcium and sodium movement in healthy and diseased cardiac myocytes.
    Author: Sag CM, Wagner S, Maier LS.
    Journal: Free Radic Biol Med; 2013 Oct; 63():338-49. PubMed ID: 23732518.
    Abstract:
    In this review article we give an overview of current knowledge with respect to redox-sensitive alterations in Na(+) and Ca(2+) handling in the heart. In particular, we focus on redox-activated protein kinases including cAMP-dependent protein kinase A (PKA), protein kinase C (PKC), and Ca/calmodulin-dependent protein kinase II (CaMKII), as well as on redox-regulated downstream targets such as Na(+) and Ca(2+) transporters and channels. We highlight the pathological and physiological relevance of reactive oxygen species and some of its sources (such as NADPH oxidases, NOXes) for excitation-contraction coupling (ECC). A short outlook with respect to the clinical relevance of redox-dependent Na(+) and Ca(2+) imbalance will be given.
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