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  • Title: Risk factors associated with nephrocalcinosis in preterm infants.
    Author: Lee HS, Sung IK, Kim SJ, Youn YA, Lee JY, Lim GY, Im SA, Ku YM, Lee JH, Kim SY.
    Journal: Am J Perinatol; 2014 Apr; 31(4):279-86. PubMed ID: 23733706.
    Abstract:
    PURPOSE: The objective was to identify the risk factors associated with nephrocalcinosis (NC) in preterm infants. METHODS: NC was diagnosed by renal sonography at 4 or 8 weeks of life, and 10 infants who had findings of type 3 or 4 NC were classified as the NC group. Various clinical and laboratory factors were compared between NC and control groups. RESULTS: Serum sodium (Na) on day 1, serum creatinine and fractional excretion of calcium (FeCa) at 1 and 2 weeks, and serum calcium (Ca), fractional excretion of sodium (FeNa), and urine Na on 2 weeks of life were significantly different between the two groups: the NC group showed significantly higher serum creatinine, FeNa, and FeCa than the control group, suggesting a greater decrease in renal function in the NC group. Differences of the laboratory findings disappeared after 4 weeks of life. The strongest risk factor was birth weight. CONCLUSION: A transient decrease in renal function during the first 2 weeks of life was associated with development of NC in preterm very low-birth-weight infants, and the risk of NC increased as birth weight decreased.
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