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  • Title: A new steroidal glycoside from the seeds of Hyoscyamus niger.
    Author: Zhang W, Zhang W, Luo J, Kong L.
    Journal: Nat Prod Res; 2013; 27(21):1971-4. PubMed ID: 23745717.
    Abstract:
    A new steroidal glycoside hyoscyamoside G (1), together with two known analogues hyoscyamoside E (2) and hyoscyamoside F1 (3), was isolated from the seeds of Hyoscyamus niger. The structure of 1 was established as (22R,24Z)-1α,3β,7β,22,26-pentakishydroxylergost-22-O-β-d-gulcopyranosyl-5,24-diene-26-O-β-d-glucopyranoside, by means of chemical and spectroscopic methods including HRESI-MS, 1D and 2D NMR. In vitro, compound 2 showed cytotoxicity against human lung cancer cell H460 with IC50 value of 66 μg/mL.
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