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  • Title: Blocking HIV-1 gp120 at the Phe43 cavity: if the extension fits….
    Author: Dey B, Berger EA.
    Journal: Structure; 2013 Jun 04; 21(6):871-2. PubMed ID: 23747109.
    Abstract:
    The Phe43 cavity is a mysterious feature in crystallographic structures of HIV-1 gp120-CD4 complexes. In this issue of Structure, Acharya and colleagues provide structural explanations for the potent neutralization by CD4 mimetic miniproteins with chemical extensions that fit into this cavity.
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