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  • Title: Hypertonic saline in elevated intracranial pressure: past, present, and future.
    Author: Surani S, Lockwood G, Macias MY, Guntupalli B, Varon J.
    Journal: J Intensive Care Med; 2015 Jan; 30(1):8-12. PubMed ID: 23753247.
    Abstract:
    Hypertonic Saline (HS) has been a proven and effective therapy and a safe alternative to mannitol in patients with increase intracranial pressure (ICP). We hereby present a case of 25-year-old women with intracranial bleed secondary to right parietal arteriovenous malformation. Patient underwent surgery for evacuation of hematoma and resection of arteriovenous malformation. Post- operative course was complicated by recurrent episodes of elevated ICP. She received total of 17 doses of 23.4% HS and 30 doses of mannitol with good outcome. Despite reluctance from some clinicians to use HS, hypertonic saline seems to be a safe and effective therapy.
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